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An Iodine Treatments Effect on Cell Proliferation Rates of Breast Cancer Cell Lines; In Vitro Study

Elliyanti, Aisyah and Susilo, V. Yulianti and Setyowati, Sri and Visweswara Rao, Pasupuleti (2020) An Iodine Treatments Effect on Cell Proliferation Rates of Breast Cancer Cell Lines; In Vitro Study. Open Access Macedonian Journal of Medical Sciences, 8 (B). ISSN 1857-9655

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Abstract

BACKGROUND: Iodine can reduce breast tumor progression by mediates an antiproliferative effect. AIM: This study aimed to investigate the effect of iodine (I2), Lugol (I3K), and the combination of both on cell proliferation of three different types of breast cancer cell lines. METHODS: The samples were MCF7, SKBR3, and MDA-MB 213 cell lines. Cell proliferation rate was measured using colorimetric and clonogenic assays. RESULTS: The cell proliferation rate of MDA-MB 231 cells was reduced significantly by treatment I2, I3K, and combination of both with p = 0.046, p = 0.00, and p = 0.00, respectively. In MCF7 cells, I2 reduced the cell proliferation of 54–94% and I3K reduced the proliferation of 74–94%. The effectiveness of I3K treatments in slowing cell proliferation rate was dose-dependent. In SKBR3 cells, I2reduced proliferation cell up to 85% and I3K 4%-94% depending on the dose. Clonogenic assay results showed a discontinue of the cell proliferation by all doses of I2 and I3K (10 μM and 20 μM). CONCLUSION: Breast cancer cell lines, representing subtypes of luminal A, HER2+, and triple-negative, show an excellent response to iodine treatments and I3K response shows in a dose-dependent manner. Further studies are needed to investigate the effective in vivo doses.

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radiofarmaka
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: EDITOR PTRR BATAN
Date Deposited: 04 Jul 2021 03:43
Last Modified: 04 Jul 2021 03:43
URI: http://repo-nkm.batan.go.id/id/eprint/10392

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