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Stabilitas Radiokimia Nanopartikel Perak Terlabel I-131

Sarmini, Endang and Lestari, Enny and Abidin, Abidin and Sriyono, Sriyono and Sholikhah, Umi and Widyaningrum, Triani (2017) Stabilitas Radiokimia Nanopartikel Perak Terlabel I-131. Prosiding Seminar Nasional Kimia UNY 2017. pp. 297-304.

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Abstract

Stability is a factor that must be considered in making a formulation of a preparation pharmacy. Therefore, the radiochemical stability of silver nanoparticles (AgNP) is labeled Iodine-131 ( 131 I) is a very important parameter before being used for radiotherapy. Creation AgNP- 131 I can be done by the reduction method which in this AgNP research will be labeled with 131 I made with 3 different methods. The three variations of the method include synthesis of AgNP without centrifugation (Sample 1), with centrifugation 12,210 rpm 30 min, 4o C (Sample 2), and sample 3 of sample 2 was resentrifuged (8000 rpm, 15 min, 4 o C). The AgNP- 131 I solution formed from the 3 methods was tested for radiochemical stability on day 1, 2, 5 and 12 using paper chromatography method and using Autoradiography tool. Results stability testing showed 100% purity of radionuclides AgNP- 131 I and purity radiochemistry above 95% for all three methods. While the results of stability testing on the day to-12, the radiochemical stability of AgNP- 131 I still satisfies radiochemical stability parameters is above 95%

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: USER PTRR BATAN
Date Deposited: 11 Jul 2018 14:49
Last Modified: 11 Jul 2018 14:49
URI: http://repo-nkm.batan.go.id/id/eprint/3357

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