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Spontaneous and radiation-induced tumorigenesis in p53-deficient mice

Rajamanikam, Baskar and Mukh, Syaifudin and Taisei, Nomura (2002) Spontaneous and radiation-induced tumorigenesis in p53-deficient mice. International Congress Series, 1236. pp. 115-118.

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To investigate the spontaneous and radiation induced tumorigenesis, tumor development and molecular changes were examined in p53 gene-deficient mice. All of the null (p53 -/-) animals died of leukemia, sarcoma, etc. before 12 months of age, and predominantly of lymphocytic leukemia at the early age of 3 – 5 months, while heterozygous (p53+/-) and wild type (p53+/+) animals survived more than 30 and 40 months, respectively. Half of the heterozygotes developed sarcomas (osteosarcomas, rhabdomyosarcomas, hemangiomas), and some developed tumors in the lung and liver; however, a lower incidence of leukemia was found. The onset of the tumor was late in their lives in the heterozygotes, though the tumors grew rapidly. In the wild type mice, leukemia and sarcomas were rarely observed. The 137Cs g-irradiation shortened the lifespan of the heterozygotes with an earlier tumor development, though this effect was not evident in the null mice. Among the 54 spontaneous tumors studied in the heterozygotes, 12 (22.2%) showed loss of the wild type p53 allele (loss of heterozygosity, LOH) and one functional mutation was found at exon 6 of the p53 gene. All the LOH was found in leukemia and sarcomas, except in one breast carcinoma. D 2002 Elsevier Science B.V. All rights reserved.

Item Type: Article
Subjects: Keselamatan dan Keamanan Nuklir > Keselamatan Radiasi dan Kesehatan kerja
Divisions: Pusat Teknologi Keselamatan dan Metrologi Radiasi
Depositing User: USER PTKMR BATAN
Date Deposited: 11 Sep 2018 22:39
Last Modified: 11 Sep 2018 22:39
URI: http://repo-nkm.batan.go.id/id/eprint/3897

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