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Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate

Fauzia, Ratna Putri and Mutalib, Abdul and Soedjanaatmadja, R. U. M. S. and Bahti, H. H. and Anggraeni, A. and Gunawan, Adang Hardi and Pujiastuti, H. and Hidayati, Y. (2015) Synthesis and Characterization of Gadolinium Diethylenetriamine Pentaacetate-Folate. Procedia Chemistry, 17. pp. 139-146. ISSN 1876-6196

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Abstract

In our preliminary radiopharmaceutical study, 153Gd-DTPA-Folate has been successfully prepared, and tested for its bio-distribution. This continuing study is aimed at synthesizing and characterizing Gd-DTPA-Folate. The synthesis was started with the preparation of a derivative of folic acid, EDA-Folate, which was subsequently reacted with DTPA-Dianhydride to form DTPA-Folate. Finally, DTPA-Folate was reacted with Gd3+ to result in Gd-DTPA-Folate, on a 0.1-10 gram scale, with a yield of 97.2%. Experimental data collected from characterization of purified synthetic products using ultraviolet, infrared, and mass spectroscopy, indicated the formation of Gd-O and Gd-N bonds leading to the formation of Gd-DTPA-Folate molecule.

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: USER PTRR BATAN
Date Deposited: 19 Apr 2018 04:45
Last Modified: 19 Apr 2018 04:45
URI: http://repo-nkm.batan.go.id/id/eprint/402

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