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SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM CONTENT IN 99MTC SOLUTION VIA MO-TGA-KSCN COMPLEXES FORMATION

Febrian, Muhammad Basit and Mulyati, Titin Sri and Suherman, Ade and Adventini, Natalia and Setiadi, Yanuar and Setiawan, Duyeh and Aziz, Azmairit (2018) SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM CONTENT IN 99MTC SOLUTION VIA MO-TGA-KSCN COMPLEXES FORMATION. Jurnal Sains dan Teknologi Nuklir Indonesia, 19 (2). pp. 71-80. ISSN 1411-3481

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Abstract

SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM CONTENT IN 99mTc SOLUTION VIA Mo-TGA-KSCN COMPLEXES FORMATION. Quality of Technetium-99m solution is determined from its radiochemical, radionuclidic and chemical purity. One of the major concern about chemical purity of Tc-99m from irradiated natural molybdenum is its molybdenum content or Mo breaktrough. Spectrophotometric method is one of method that could be applied for Mo determination in Tc-99m solution. Molybdenum (V) could form a colored complexes with potassium thiocyanate (KSCN) but Molybdenum (VI) must be reduced before formed a complexes with KSCN. Thioglycolic Acid (TGA) was used as reducing agent to obtain reduced Mo (Mo(V)). A series of optimization process was carried out to find optimum condition of complex formation for analysis purposes. Optimized condition were 3 mL of 25% HCl was added into a volume of Mo sample, followed by 200 µL of 10% TGA, 1 mL of 10% KSCN, and water addition up to 10 mL total volume. The method is linear over 2 ppm to 30 ppm Mo with regression coeffisient 0.9988±0.0007. The detection limit was 0.212 ppm Mo. Color of the complex has a stability of absorbance up to 120 minutes while stored at room temperature. No significant deviation occured when 1000 ppm of oxalic acid, methyl ethyl ketone and iron added into sample solution. This complexing method is suitable for spectrophotometric determination of molybdenum content in Tc-99m solution as a part of quality control process.

Item Type: Article
Subjects: Isotop dan Radiasi > Pemanfaatan Isotop dan Radiasi > Bidang Kesehatan
Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Divisions: Pusat Sains dan Teknologi Nuklir Terapan
Depositing User: user pstnt batan
Date Deposited: 14 Nov 2018 03:18
Last Modified: 14 Nov 2018 03:18
URI: http://repo-nkm.batan.go.id/id/eprint/4445

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