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pH Effect of Gold Nanoparticles Synthesis Encapsulation in Polyamide Amine Generation 3.0 (AuNP-PAMAM G3.0)

Pujiyanto, Anung and Lestari, Enny and Kurniasih, Dede and Mujinah, Mujinah and Sholikhah, Umi and Gunawan, Adang and Sarah, Amalia and Mutalib, Abdul (2018) pH Effect of Gold Nanoparticles Synthesis Encapsulation in Polyamide Amine Generation 3.0 (AuNP-PAMAM G3.0). Research Journal of Chemistry and Environment, 22 (2). 214 -219. ISSN 278-4527

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Text (At the moment, one of AuNP development is AuNP encapsulated polyamide amine third generation (AuNP-PAMAM G 3.0).)
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Abstract

The unique properties of gold nanoparticles (AuNP) allow them to be used as drug and gene delivery agent, so they are effective in diagnosis and therapy. At the moment, one of AuNP development is AuNP encapsulated polyamide amine third generation (AuNP-PAMAM G 3.0). The synthesis of AuNPPAMAM G 3.0 can be done by reacting HAuCl4 with PAMAM G3.0, then adding NaBH4 as a reducing agent. This makes AuNP-PAMAM G 3.0 to be strongly influenced by the pH reaction. The results of this study show that AuNP has sizes ranging from 11 to 19 nm at pH 2 while their sizes are 2 to 5 nm at pH 7 and 9. The separation using Sephadex PD-10 column shows that the elution efficiencies are 10% at pH 2, 40% at pH 7 and 50% at pH 9. Gold nanoparticles at pH 7 and 9 are more stable than pH 2 in saline. Based on the above results, it is shown that AuNP could be encapsulated by PAMAM G3.0 at pH 7 and 9 but AuNP at pH 2 could not.

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radiofarmaka
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: USER PTRR BATAN
Date Deposited: 29 Nov 2018 12:27
Last Modified: 29 Nov 2018 12:27
URI: http://repo-nkm.batan.go.id/id/eprint/6534

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