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Evaluation of Lymphocytes Proliferation in Botteng Village (A High Background Radiation Area) Inhabitants Using Binucleate Index

Dwi, Ramadhani and Sri, Sardini and Masnelli, Lubis and Mukh, Syaifudin (2016) Evaluation of Lymphocytes Proliferation in Botteng Village (A High Background Radiation Area) Inhabitants Using Binucleate Index. Jurnal Ilmiah Aplikasi Isotop dan Radiasi, 12 (2). pp. 107-112. ISSN 1907-0322

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Abstract

Botteng Village in Mamuju, West Sulawesi was known for the high natural background radiation exposure. Botteng Village inhabitants exposed to high natural radiation in their daily life. Radiation exposure can inhibit the mitosis mechanism at various phases. Our previous study revealed that mitotic and nuclear division indexes in Botteng Village inhabitants were lower compared to control samples. To validate our previous study results here we evaluate the binucleate index in peripheral blood lymphocytes of Botteng Village inhabitants. Blood samples were collected from thirteen healthy adult subjects in Botteng Village and thirteen healthy adult subjects in normal background radiation area. Binucleate index was calculated as the proportion of binucleated cell (BNC) in 500 cells for each sample. The study result showed that the BI in Botteng Village was similar compared to control group (23.58 ± 9.60 vs 23.47 ± 6.24). It is possible that the small sample numbers used in this study were not adequate to represent the BI value in Botteng Village inhabitants. This study also showed that there was insignificant difference of BIin respect to gender and age for all samples. Further study using larger sample number should be conducted to verify whether the BI can be used as a marker of lymphocytes proliferation.

Item Type: Article
Subjects: Keselamatan dan Keamanan Nuklir
Keselamatan dan Keamanan Nuklir > Keselamatan Radiasi dan Kesehatan kerja
Divisions: Pusat Teknologi Keselamatan dan Metrologi Radiasi
Depositing User: USER PTKMR BATAN
Date Deposited: 04 May 2018 13:11
Last Modified: 04 May 2018 13:11
URI: http://repo-nkm.batan.go.id/id/eprint/780

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