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Micronucleus Frequencies in Mononucleated Cells of People Living in Takandeang Village – A High Level of Natural Radiation Area in Indonesia

Sofiati, Purnami and Masneli, Lubis and Siti, Nurhayati and Suryadi, Suryadi and Dwi, Ramadhani and Mukh, Syaifudin (2018) Micronucleus Frequencies in Mononucleated Cells of People Living in Takandeang Village – A High Level of Natural Radiation Area in Indonesia. Jurnal Ilmiah Aplikasi Isotop dan Radiasi, 14 (2). pp. 117-124. ISSN 1907-0322

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Abstract

The evaluation of micronucleus in mononucleated cells (MNMNC) could give a more comprehensive information about genomic instability in population exposed to high level of natural background radiation. Here in this study the evaluation of MNMNC in Takandeang Village, Mamuju inhabitants was performed to obtain more clearly information about genomic instability in population exposed to high level of natural background radiation. Twenty seven healthy adult subjects from Takandeang Village and normal background radiation area were included in this study. Results showed that mean MNMNC of Takandeang Village inhabitants were significantly higher compared to control samples [3.96 ± 0.488 vs 1.96 ± 1.675; p<0.05]. The age and gender factors did not affect the MNMNC in all samples (p>0.05). It is possible that the high background radiation exposure received by Takandeang Village inhabitants induced the aneugenic effect in lymphocytes. Overall our study showed that scoring of MNMNC can provide additional information in cytokinesis block micronucleus (CBMN) assay.

Item Type: Article
Subjects: Keselamatan dan Keamanan Nuklir > Keselamatan Lingkungan > Keselamatan Radiasi Lingkungan
Divisions: Pusat Teknologi Keselamatan dan Metrologi Radiasi
Depositing User: USER PTKMR BATAN
Date Deposited: 20 Jun 2019 05:45
Last Modified: 20 Jun 2019 05:45
URI: http://repo-nkm.batan.go.id/id/eprint/9074

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