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Assessment of Individual Radiosensitivity in Inhabitants of Takandeang Village - A High Background Radiation Area in Indonesia

Dwi, Ramadhani and Sofiati, Purnami and Siti, Nurhayati and Masneli, Lubis and Devita, Tetriana and Wiwin, Mailana and Kristin, Dwi Purwanti and Eko, Pudjadi and Ikuo, Kashiwakura and Okayaki, R and Mukh, Syaifudin (2019) Assessment of Individual Radiosensitivity in Inhabitants of Takandeang Village - A High Background Radiation Area in Indonesia. Atom Indonesia, 45 (1). pp. 27-35. ISSN 0126-1568

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Abstract

People living in high background radiation areas (HBRAs) possibly develop the radioadaptive response (RAR) phenomenon. The Mamuju area in West Sulawesi Indonesia is known as an HBRA in Indonesia due to its high natural uranium contents. It is possible that RAR has developed in Mamuju inhabitants. To prove this hypothesis, here in this study, evaluation of the individual radiosensitivity in the inhabitants of Takandeang Village, Mamuju, was conducted using G2 micronucleus (MN) assay. Association between blood groups and TP53 Arg72Pro polymorphism with individual radiosensitivity was also evaluated in this study. Using G2 MN assay, we assessed the individual radiosensitivity of Takandeang Village inhabitants and control samples. For each sample, three parameters were calculated. The spontaneous (baseline) MN number, MN number after 0.5 Gy in vitro irradiation, and radiation-induced MN were calculated to predict the individual radiosensitivity. The radiation-induced MN was defined by subtracting the spontaneous MN number from the MN number after irradiation. The mean and SD of the number of micronuclei induced by radiation found in control group (CG) was set as the cutoff value to determine the individual radiosensitivity in all samples. The occurrence of a radiation-induced MN value higher than the mean CG + 1SD CG was scored as 1, indicating a milder radiosensitive phenotype, whereas a result higher than the mean CG + 2SD CG was scored as 2, and indicated a more severe radiosensitive phenotype. When the individual value was lower than the mean CG + 1SD CG, a score of 0 was attributed to the tested subject. The results showed that four individuals in Takandeang Village inhabitants had a milder radiosensitive phenotype, while the others were categorized as normal radiosensitive. A similar finding was also found in control samples. Our study failed to find any correlation between radiosensitivity and either blood group or the TP53 Arg72Pro polymorphism. Overall, our study revealed the possibility of RAR phenomena in Takandeang Village inhabitants. Further investigation using a different point of radiation dose value and larger sample number should be performed to validate this study results.

Item Type: Article
Subjects: Keselamatan dan Keamanan Nuklir > Keselamatan Lingkungan > Keselamatan Radiasi Lingkungan
Divisions: Pusat Teknologi Keselamatan dan Metrologi Radiasi
Depositing User: USER PTKMR BATAN
Date Deposited: 20 Jun 2019 06:04
Last Modified: 20 Jun 2019 06:04
URI: http://repo-nkm.batan.go.id/id/eprint/9076

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