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Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch

Rahman, Wira and Sarmini, Endang and Herlina, Herlina and Abidin, Abidin and Triyanto, Triyanto and Hambali, Hambali and Sriyono, Sriyono and Widyaningrum, Triani (2019) Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch. Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch, 1 (3). pp. 26-31. ISSN 2406-856X

[img] Text (Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on th)
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Abstract

Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after a trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumours. Currently, keloid is treated by a conventional method e.g.by applying the bulk of 32P radioisotope directly on keloid area. However, this method is considered inefficient and less secure. The purpose of this research is to obtain a technology for preparing of 32P-labeled skin patch. The first step of this research is to produce 32P-labeled chromic phosphate (Cr32PO4) colloids, through condensation involving oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr32PO4 with particle size of <1 μm. These particles (Cr32PO4) are to expect to distribute evenly when mixed with silicon to form skin patch which will not decompose easily. Characterization of the prepared Cr32PO4colloids gave a yield of 97,8% with particle size of greater than > 1μm. Further study needs to be performed in due time in order to have Cr32PO4 colloids with a suitable particle size.

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: USER PTRR BATAN
Date Deposited: 18 Oct 2019 16:52
Last Modified: 18 Oct 2019 16:52
URI: http://repo-nkm.batan.go.id/id/eprint/9382

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