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Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography

Maskur, Maskur and Lestari, Enny and Putra, Amal and Kurniasih, Dede and Sarmini, Endang and Tahyan, Yayan and Gunawan, Adang and Aries, Arni (2019) Determination of Radiochemical Purity of 99mTc-DTPA Using One-System Method of Paper Chromatography. The Journal of Pure and Applied Chemistry Research, 8 (2). ISSN 2541-0733

[img] Text (The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours.)
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Abstract

The more efficient and effective quality control techniques for 99mTc-DTPA are needed because 99mTc has a short half-life of around 6.0 hours. We have succeeded in developing a one-system of TLC for radiochemical purity testing system that is faster and more practical. Two-system method of TLC for radiochemical purity testing uses mobile phase of methyl ethyl ketone as an A and 0.9% sodium chloride solution as a B. One-system method uses the mobile phase of a mixture solution of acetone and 0.9% sodium chloride. In this study, the determination of radiochemical purity of the one-system of TLC has been successfully developed using the Whatman-1 paper stationary phase and the mixed mobile phase between acetone and 0.9% sodium chloride solution. The mobile phase of acetone: 0.9% sodium chloride with a ratio of 9:1 shows the most optimum results. This phase can separate 99mTc-DTPA (Rf = 0.4-0.6) from 99mTcO4- (Rf = 0.9-1.0) and 99mTcO2 (Rf = 0.0-0.1) as radiochemical impurities. This result shows that the one-system of TLC method can be used for radiochemical purity testing of 99mTc-DTPA radiopharmaceutical kits. This method can completely separate the product compound (99mTc-DTPA) from its impurities (99mTcO2 and 99mTcO4-).

Item Type: Article
Subjects: Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radioisotop
Isotop dan Radiasi > Produksi Isotop dan Sumber Radiasi > Teknik Produksi Radiofarmaka
Manajemen > Sistem Mutu > Inspeksi / Kendali Mutu
Divisions: Pusat Teknologi Radioisotop dan Radiofarmaka
Depositing User: USER PTRR BATAN
Date Deposited: 18 Oct 2019 16:53
Last Modified: 18 Oct 2019 16:53
URI: http://repo-nkm.batan.go.id/id/eprint/9389

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