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Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system

Kusrini, Eny and Prassanti, Riesna and Nurjaya, Dwi Marta and Gunawan, Cindy (2017) Multifunctional microsphere formulation of fluorescent magnetic properties for drug delivery system. In: The First International Symposium of Biomedical Engineering (ISBE 2016), 31 May–1 June 2016, Depok City, Indonesia.

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Abstract

The microsphere formulations of Chit/TPP/Sm/Fe3O4/Rn were prepared by an ionic gelation technique, where Chit = chitosan, TPP = tripolyphosphate, Sm = samarium and Rn = ranitidine. Optimum of microsphere formulation exhibit magnetic and fluorescent properties with adsorption efficiency of ~92% was obtained for Chit/TPP/Sm/Fe3O4/Rn with ratio 400:500:50:1:20. Fluorescence intensity of microsphere formulations increased with the cumulative amount release of ranitidine, so that the changing of fluorescence intensity at wavelength of 590 nm referring to the Sm3+ ion could be used as indicator in DDS. With the demonstration of sustained release from microsphere formulation, it allows to investigate the applications to other drugs.

Item Type: Conference or Workshop Item (Paper)
Subjects: Daur Bahan Bakar Nuklir dan Bahan Maju > Bahan Galian Nuklir > Teknik Pengolahan Bahan Galian Nuklir
Divisions: Pusat Teknologi Bahan Galian Nuklir
Depositing User: Unnamed user with email kurnias@batan.go.id
Date Deposited: 04 May 2018 09:58
Last Modified: 04 May 2018 09:58
URI: http://repo-nkm.batan.go.id/id/eprint/943

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