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Genetic polymorphism in DNA base excision repair gene XRCC1 among medical radiation workers

Harry Nugroho Eko, Surniyantoro and Yanti, Lusiyanti and Wiwin, Mailana and Devita, Tetriana (2019) Genetic polymorphism in DNA base excision repair gene XRCC1 among medical radiation workers. Journal of the Medical Sciences, 51 (4). pp. 301-308.

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Abstract

X-rays repair cross-complementing group 1 (XRCC1) gene is one of the gene that plays an important role in base excision repair system (BER) and DNA repair both single and double strand breaks. Individuals with XRCC1 exon 10 (Arg399Gln) gene polymorphisms and carrying 399Gln allele variants (A allele) have a greater risk of DNA damage than their wildtype, 399Arg. The aim of this study was to examine the genotype frequencies of single nucleotide polymorphisms (SNPs) of XRCC1 exon 10 among medical radiation workers. This study involved 77 samples from several hospitals in Indonesia. Genotyping of XRCC1 exon 10 gene polymorphism was performed using PCR-RFLP. Individuals carrying A allele had lower frequency than that is carrying their wild type of 399Arg (0.39 vs. 0.61). The results indicated that 39% of medical radiation workers had a risk of repair efficiency of DNA damage and might influence an individual’s risk of cancer. Ionizing radiation induces many types of damage to DNA, requiring multiple repair pathways to restore genomics integrity. Other important genes/pathways, especially those for DNA doublestrand break repair, might also play a role and should be further investigated. Furthermore, polymorphisms leading to inefficient DNA repair might also be associated with late reactions to radiotherapy.

Item Type: Article
Subjects: Keselamatan dan Keamanan Nuklir > Keselamatan Radiasi dan Kesehatan kerja > Proteksi Radiasi
Divisions: Pusat Teknologi Keselamatan dan Metrologi Radiasi
Depositing User: USER PTKMR BATAN
Date Deposited: 13 Nov 2019 03:48
Last Modified: 13 Nov 2019 03:48
URI: http://repo-nkm.batan.go.id/id/eprint/9444

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